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- Table of Contents
Facts about Potassium voltage-gated channel subfamily C member 2.
Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15709110).
Human | |
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Gene Name: | KCNC2 |
Uniprot: | Q96PR1 |
Entrez: | 3747 |
Belongs to: |
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potassium channel family |
Potassium voltage-gated channel subfamily C member 2
Mass (kDA):
70.226 kDA
Human | |
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Location: | 12q21.1 |
Sequence: | 12; NC_000012.12 (75040078..75209839, complement) |
Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Perikaryon. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome. Cell junction, synapse. Apical cell membrane. Basolateral cell membrane. Colocalizes with parvalbumin in globus pallidus neurons. Localizes in thalamocortical axons and synapses. Localizes on the surface of cell somata, proximal dendrites and axonal membranes. Also detected throughout the neuropil. Localized in st
PMID: 8111118 by Haas M., et al. Localization of Shaw-related K+ channel genes on mouse and human chromosomes.
PMID: 10414303 by Rudy B., et al. Contributions of Kv3 channels to neuronal excitability.